application of clemmensen reduction

Screening for hypoglycaemic activity was performed on chloroform, methanol and aqueous extracts of the barks of S. pinnata at doses of 300 mg/kg and glibenclamide (2.5 mg/ kg, p.o.) The antipyretic activity of the methanol extract showed significant effect on yeast-induced fever in rats at doses of 400 and 600 mg/kg. of S. pinnata barks was screened for analgesic, anti-inflammatory and antipyretic activity. Aliphatic and aromatic compounds have been employed and have shown different chemical deportments. The methanol extract of N. cadamba barks upon concentration under reduced pressure left a sticky with light brown stain residue (8.6%) which gave positive ferric and Shinoda tests for flavonoids and negative Liebermann-Burchard reaction. Maximum reduction was seen at doses of 200 and 400 mg/kg (34.08% and 48.94% decrease respectively) after 6 h of extract administration. The compounds were characterized through chemical and spectral analysis and confirmed as Acacetin, Apigenin and Quercetin respectively. In antihyperglycaemic study, the rise in the blood glucose level was observed after 24 h of alloxanization to the animals. In TLC examination of the residue showed number of spots (Solvent system: Benzene: Chloroform: Ethyl acetate. in our. The study revealed that the root extract caused significant reduction in the blood glucose level in both normoglycaemic and alloxan induced diabetic rats at the tested dose levels in a dose dependant manner. The fifth chapter describes the extraction processes adopted and preliminary phytochemical study of different extractives. The antipyretic activity of the methanol extract was tested in yeast-induced pyrexia in rats. time taken for paralysis/death of the worms. The present study therefore justifies its use in the folklore remedies as an anthelmintic drug of natural origin. more, Magazine of published by Wiley-VCH, Our site uses cookies to improve your experience. Reports of the normoglycaemic study of N. cadamba barks reveals that the chloroform extract produced marked reduction in blood glucose concentration from 2 h of administration at tested dose levels in normoglycaemic animals where as glibenclamide showed the activity from 1 h, simultaneously methanol extract also reduced blood glucose level. ISBN: 978-0-471-70450-8 You can find out more about our use of cookies Petroleum ether extract on the other hand did not increase urinary electrolyte concentration. The present review includes examples that are solely condensation reactions of aldehydes and ketones. The dried powdered bark was extracted successively with various solvents viz. Licence. Generally writhing test used for mechanical visceral pain model screening of antinociceptive effects and the tail immersion test is another thermic pain model, which is selective to centrally. All the test extracts possess hypoglycemic activity as they lowered blood glucose level in both normal and diabetic rats. was used as the reference drug. but the effect was found to be the less potent in increasing the urinary out put when compared with the reference standard. aldehydes or alpha,beta-unsaturated ketones formed by dehydration of intermediate beta-aldols or beta-ketals. Chapter 7.3 describes the phytochemical examination methanol extract of the barks of S. pinnata. [3] S. Caron, Practical Synthetic Organic Chemistry, John Wiley & Sons, New York, USA, 2011. The compounds were characterized through chemical and spectral analysis and confirmed as -Sitosterol (C-01) Lupeol (C-02) and Betulinic acid (C-03) respectively. The extract at 200, 400 and 600 mg/kg, p.o. Screening for diuretic and laxative activity was performed on petroleum ether, chloroform and methanol extracts of the barks of S. pinnata. Petroleum ether extract on the other hand did not increase urinary electrolyte concentration. In present study, the methanol extract of N. cadamba significantly increased the urinary out put as well as urinary electrolyte concentration at the tested dosage regimen that is comparable with the reference standard except in increasing the urinary out put. Among the tested extracts, the aqueous extract was found to possess promising anthelmintic activity in comparison to other extracts. The sixth chapter depicts various pharmacological studies of the selected medicinal plants. The results of the methanol extract are comparable to that of the reference standard glibenclamide. The term aldol condensation has also been applied to many other condensations involving the reaction of an aldehyde or ketone., c Rates of hydration, dehydration, and retroaldol condensation were competitive for 3-penten-2-one and were calculated to be 7.6 × 10-3, 2.3 × 10-3, and 1.6 × 10-4 M-1 s-1, respectively, at 40°C. and pentazocine (30 mg/kg, p.o.) The various solvents were purified by distillation and used for the extraction. -Clemmensen reduction is an organic reduction reaction shown by both aldehydes and ketones, But Carboxylic acid (-COOH) group can't be reduced by this method (but the … This year marks the 100th anniversary of Erik Christian Clemmensen’s first report of the reduction that now bears his name. The activities were compared with the reference drug piperazine citrate. Design, Synthesis, Crystallographic studies and antimicrobial activities of novel chalcones and oxazolidinone derivatives. The anthelmintic activity of various extracts of the roots of C. rutidosperma was studied against Indian earthworms Pheritima posthuma using piperazine citrate (15 mg/ml) as reference standard. A brief note on the present status of the medicinal plants in India was discussed. These condenations are discussed. of N. cadamba barks was screened for analgesic, anti-inflammatory and antipyretic activity. Thus, diuretics play an important role in hypertensive patients. and agar-agar (300 mg/kg, p.o.) A simple and efficient method has been developed for selective single aldol condensation between acetone and various aromatic/heterocyclic aldehydes using aqueous sodium hydroxide at 5–10°C.

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