carica papaya journal

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The application of papaya extract showed an increase in the number of wound lengths that healed compared to the negative control group that applied aqua destilata.

0000012023 00000 n Beforehand, mice were anesthetized using topical lidocaine ointment. Toggle facets Limit your search Text Availability. The 100% concentration then was diluted to a concentration of 25%, 50%, and 75% according to the concentration dilution formula. �A�9�%�e���9�E���%E�� investigated topical hydrogel containing Fumaria vaillantii Loisel. <<17d74dbe95b74947a07a9a1fc3d0be3b>]>> %����

Mi Hyun Kang and Bae-Hwan Kim found that water extract of acai berry also had oral wound healing effect both clinically and histologically [13]. 21 0 obj B. Erinfolami, “Glycemic and wound healing Effects of aqueous mesocarp extract of unripe, S. Yamna Zia, “Wound and its healing: a concise physiological review,”, Bainbridge, “Wound healing and the role of Fibroblast,”, F. D. Roodbordeii, M. Afshar, F. H. A. Tabrizi et al., “Topical hydrogel containing Fumaria vaillantii Loisel. The wound length began to decrease on the eighth day, but two mice (Nos. <>stream

We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. 0000001416 00000 n

In this group, the length of the wound began to reduce on the fourth day. O6�$~(�m,S[� endobj Wound healing is a process of the body replacing devitalized and missing tissue in order to fill the lost and repair the damaged. 1 0 obj Citation in PubAg 22; Full Text 2; Journal. 0000004420 00000 n 0000011134 00000 n endobj Tgk.

(D) The existence of areas where fibrillation did not occur. 0000000776 00000 n <>stream In this group, the length of the wound began to decrease on the fourth day. This research is an experimental laboratory research (in vivo) using the design of the posttest-only control group and uses grouping based on a completely randomized design (CRD).

endobj 23 0 obj The results of the application of papaya extract concentrations of 25%, 50%, and 75%, as well as distilled water, showed healing that was marked by a reduction in wound length. endstream

Carica papaya is sometimes known as paw paw which is a fast growing herbaceous plan, it belongs to the Caricaceae family (1).This plant is a dicotyledonous, polygamous and diploid spieces.It originated from Southern mexico,Central America and the Northen part of South America (2).It is a rich source of three powerful antioxidant which is vitamin C,vitamin A and vitamin E. Carica papaya belonging to the genus Carica. The authors declare that they have no conflicts of interest. The results of the histologic feature can be seen in Figure 2. We are committed to sharing findings related to COVID-19 as quickly as possible.


VI in the negative control group died after injury. endobj Each sample group was treated with the same wound, which was twice a day using a disposable microapplicator. 18 0 obj Ismail Hossain1, Md. %PDF-1.5

(a) Histological view of negative control on day 14. endstream endstream Traditional and Medicinal Uses of Carica papaya. Many researchers that investigated wound healing found that topical administration of herbal gel formulation significantly enhances wound healing in rats.

�8�ˋ����--��/>^�\����c��S��]��"�$��.~^��?Z9��{q�i~sM��Yr��TF0)� In the granulation tissue, fibroblasts are activated and play a vital role in supporting normal wound healing, involved in key processes such as breaking down the fibrin clot, creating new extracellular matrix (ECM) and collagen structures to support the other cells associated with effective wound healing, and contracting the wound [10]. (B) Slight fibers and not tight. <>

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G. abstract Papaya, botanical name Carica papaya, is an lozenge tropical fruit, often seen in orange-red, yellow-green and yellow-orange hues, with a rich orange pulp. extract enhances wound healing in rats,”, M. S. F. Magalhães, F. V. Fechine, R. N. d. Macedo et al., “Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats,”, M. H. Kang and B.-H. Kim, “Oral wound healing effects of acai berry water extracts in rat oral mucosa,”. Each group of samples was treated for the same wound, which is twice a day at 08 : 00 AM and 08 : 00 PM West Indonesia Time. (F) Inflammatory cells (HE, 10 × 40). The results of the measurement of the wound length of each treatment group can be seen in Table 1.

Different parts of this plant such as seeds, leaves, fruits, peels, roots, and stems have been previously reported to possess nutritional and medicinal values. x�b```�V�``��0pL`b`�9��xG����� <>/ExtGState<>>>/Filter/FlateDecode/Length 147/LastModified(D:20170617021739+05'30')/Group<>/PieceInfo<>>>>>stream 0000005298 00000 n 0000003903 00000 n endobj x�MM��0��7꠴�Q܄���h��@�j��H!��W��#�5j��6�A7����7��8��,>�Ko�@zNS?��2E����UQ9[��Y g��j��kxXl�"X��}v�?��(w�+Zq��П?��bW��J-�

This study used four treatments, namely, the control group negative (K0), treatment group I (P1), treatment II (P2), and treatment III (P3). 14 0 obj Carica papaya (Figure 6.4) is a herbaceous succulent plant popularly known as pawpaw, and belongs to the Caricaceae family. 0000007289 00000 n Carica papaya is a perennial large herbaceous plant known for diverse biological activities. author(s) Aravind. endobj Observations were made clinically by assessing the length of wound closure measured every day for 14 days using periodontal probe (UNC-15). <> B*͸���P܀��qݓgp|�XT��C�|'YB[0² )��Z�Y��a^��H5�d��CZ. endobj G, Debjit Bhowmik, Duraivel. 12 0 obj <>/Font<>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]>>/Parent 4 0 R/Group<>/Tabs/S/Type/Page/StructParents 0>> }a�.����N����i]�nF���O�����||��|�����x6�����'Oϒ��_�����,5�&Y��¯)�Ň�r��y�8�Z�L����ӡ�|Z���T�`���&�z�@ʺL}Y$��\���$��6-}pH=�I �����EgL� E�@� m�� endstream endobj 20 0 obj<> endobj 22 0 obj<> endobj 23 0 obj<>/Font<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 24 0 obj<> endobj 25 0 obj<> endobj 26 0 obj<> endobj 27 0 obj<> endobj 28 0 obj<> endobj 29 0 obj<> endobj 30 0 obj<> endobj 31 0 obj<> endobj 32 0 obj<> endobj 33 0 obj<>stream gmj\�K���,TL�� 0 The leaves of Carica papaya have been used as remedy for various disorders, including cancer. investigated effect of a combination of medium-chain triglycerides, linoleic acid, soy lecithin, and vitamins A and E on wound healing in rats, and the results did not accelerate the process of tissue repair by secondary union [12]. extract enhances wound healing in rats [11].

0000001014 00000 n B. Moosavi, M. Bahadoram, and N. S. Maram, “The topical effect of grape seed extract 2% cream on surgery wound healing,”, T. V. A. Lordani, C. E. D Lara, F. B. P. Ferreira et al., “Therapeutic effects of medicinal plants on cutaneous wound healing in humans: a systematic review,”, A. Eslami, C. L. Gallant-Behm, D. A. Hart et al., “Expression of integrin, C. Politis, J. Schoenaers, R. Jacobs, and J. O. Agbaje, “Wound healing problems in the mouth,”, N. Ibrahim, S. Wong, I. Mohamed et al., “Wound healing properties of selected natural products,”, L. F. Santana, A. C. Inada, B. L. S. do Espirito et al., “Nutraceutical potential of, M. M. C. Anyakudo and A. (b) Histological overview treatment group I. Journal of Medicinal Plants Research Full Length Research Paper Antibacterial activities of ethyl acetate and methanol leaf extracts of Psidium guajava and Carica papaya on bacterial pathogens isolated from manual toothbrushes Ani S. E.1, Iroha I. R.2, Moses I. B.2*, Ugbo E. …


endobj 3 0 obj Extraction of papaya leaves (Carica papaya L.) using Ultrasonic Cleaner has been performed. VI) experienced healing which was marked by a reduction in wound length to 0 mm. ��"�#ﰌ�ZI�^�����=�����9�%Ϝy����Db#Yƍ(�R���������LJ��2��^�WуK�'S�4��Lpg5i.�شC��͘"ԐkD@�|��4�C�܆N:��)� �|g�ۉ��~C+C��~�o����"]sϸ�&5���6���؂B���l��4��VK��"X ä�03¨�K��Io��9 ���

0000004496 00000 n The topical effect of grape seed extract 2% cream on surgery wound improves cellular structure and wound contraction as investigated by Hemmati et al. endobj

In the treatment group III (P3), which was applied with 75% of papaya extract, wound healing occurred along 5 mm. Journal of Medicinal Plants Studies. The data were analyzed using a one-way ANOVA test with 95% confidence interval (α = 0.05).

endobj 6 0 obj Carica papaya leaf extract is a complex of many constituents like glycosylated flavonols, esterified phenolics, organic acids, carpaine alkaloids and other yet unknown compounds. This study aimed to assess the effect of Carica papaya extract application toward incised wound healing process in mice ( Mus musculus ) clinically and histologically. 21 0 obj<>stream 3 0 obj Also, the time of wound contraction was significant in this group that can be recommended in the healing of oral surgical wounds. GK �

So, it can be concluded that Carica papaya extract had a significant effect on epithelization and fibrillation. Mohammad et al. (c) Histological Overview Treatment group II.

Review articles are excluded from this waiver policy. III and IV) had a reduction in the wound length on the fourth day and seventh day, respectively. Papaya (Carica papaya L.) is an important fruit crop of Bangladesh and is one of the most popular versatile fruits, which is also used as vegetable. 19 0 obj<> endobj Comparison of wound healing on day 14: (a) negative control group, (b) treatment group I, (c) treatment group II, and (d) treatment group III. 1, Issue 1, Part A. Papaya extract was assessed for the first time on healing of the incised wound in mice (Mus musculus) with successful results. 16 0 obj

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(A) Perfect epithelial layer. Where the formation of connective tissue restores the injured tissue, regrowth of the epithelium is seen [9]. endobj 1 0 obj (B) Fibroblast are sparse, thin, and poorly arranged. Observations were made up to the 14th day in each group of 24 mice that were sampled as many as 7 mice.
In the treatment group II (P2), which was applied with 50% of papaya extract, wound healing occurred 3–5 mm from the wound. 2 0 obj

endobj 17 0 obj <>>> 4 0 obj Ahmad N et al: Dengue fever treatment with Carica papaya leaves extracts. 15 along 5 mm with a depth reaching the alveolar bone. 2 0 obj It is native to the tropics of the Americas but now is widely cultivated in other tropical regions of the world for its edible melon-like fruit, which is available throughout the year. Magalhães et al. Terpenoids, alkaloids, flavonoids, and saponins were identified in the water extract as a phytochemical composition of papaya.

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