This reversible aldol event is subsequently followed by an enantioselective … Development of an Asymmetric Acetate Aldol Reaction with a Trifluoromethyl Ketone. This post‐aldol process takes care of the enantioselectivity issues and drives the otherwise reversible aldol reaction toward a complete conversion. Copper(I)-Catalyzed Enantio- and Diastereoselective Tandem Reductive Aldol Reaction. 1.04 Regio-, Diastereo-, and Enantioselective Addition of Organocopper Reagents onto CO and CN Bonds. *Division of Chemistry and Chemical Engineering, California Institute of Y. Yamashita, T. Yasukawa, W. Yoo, T. Kitanosono and S. Kobayashi, Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan, Instructions for using Copyright Clearance Center page. Kounosuke Oisaki, Dongbo Zhao, Motomu Kanai, Masakatsu Shibasaki. 2 Pier Giorgio Cozzi, Robert Hilgraf, Nicole Zimmermann. This aldol event is subsequently followed by a dynamic kinetic resolution process that is mediated by the same (chiral) NHC catalyst without introducing any additional substance. Also, different β-keto acids 1a–d with aromatic and alkyl substituents afforded chiral hydoxy esters 3j–n in high yields and good enantioselectivities (49–75%). The acylated aldol products bearing quaternary/tetrasubstituted carbon stereogenic centers are formed in good yields and high optical purities. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc). Aldol structural units are found in m… Catalytic enantioselective Reformatsky reaction with ketones. Ryohei Nagase, Jun Osada, Hiroaki Tamagaki, Yoo Tanabe. "Reproduced from" can be substituted with "Adapted from". Sodium Phenoxide−Phosphine Oxides as Extremely Active Lewis Base Catalysts for the Mukaiyama Aldol Reaction with Ketones. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Information. For permission to reproduce, republish and Efficient Synthesis of β-Hydroxy-α-Amino Acid Derivatives via Direct Catalytic Asymmetric Aldol Reaction of α-Isothiocyanato Imide with Aldehydes. Synthesis, characterization, oxidative electrochemistry and X-ray structures of [(Taniaphos/Walphos)MCl2] (M=Pd or Pt). Construction of contiguous tetrasubstituted chiral carbon stereocenters via direct catalytic asymmetric aldol and mannich-type reactions. Naoya Kanbayashi, Arisa Yamazawa, Koichiro Takii, Taka-aki Okamura, Kiyotaka Onitsuka. We have described a new convenient decarboxylative aldol protocol to generate highly functionalised chiral α-hydroxy esters employing a Sc(OTf)3 and PyBox catalytic system. aldol selectivity and excellent levels of enantiocontrol (eq 2, 80% yield, 4:1 anti:syn, 99% ee). Chirale Ferrocenliganden in der asymmetrischen Katalyse. Fei Wang, Xiaohua Liu, Yulong Zhang, Lili Lin, Xiaoming Feng. P. Veeraraghavan Ramachandran, Barnabas Otoo. Information about reproducing material from RSC articles with different licences The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Organosilicon and Relating Organotin Chemistry. These authors contributed equally to this work. Enatiomeric excess determined by HPLC analysis using a chiralcel column. Andreas Link, © 2014 Duan et al; licensee Beilstein-Institut. Olivier Chuzel,, Julia Deschamp,, Christophe Chausteur, and. A. Hikaru Yanai, Yasuhiro Yoshino, Arata Takahashi and Takeo Taguchi. The nucleophilic attack of carbonyls appears as a common procedure, affording chiral tertiary alcohols which are ubiquitous in the biological sciences and pharmaceutical industry [1-6].
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